Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor
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چکیده
منابع مشابه
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
Animals use their gustatory systems to evaluate the nutritious value, toxicity, sodium content, and acidity of food. Although characterization of molecular identities that receive taste chemicals is essential, molecular receptors underlying sour taste sensation remain unclear. Here, we show that two transient receptor potential (TRP) channel members, PKD1L3 and PKD2L1, are coexpressed in a subs...
متن کاملOff-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.
Ligand-gated ion channels are important in sensory and synaptic transduction. The PKD1L3-PKD2L1 channel complex is a sour taste receptor candidate that is activated by acids. Here, we report that the proton-activated PKD1L3-PKD2L1 ion channels have the unique ability to be activated after the removal of an acid stimulus. We refer to this property as the off-response (previously described as a d...
متن کاملSour Taste Responses in Mice Lacking PKD Channels
BACKGROUND The polycystic kidney disease-like ion channel PKD2L1 and its associated partner PKD1L3 are potential candidates for sour taste receptors. PKD2L1 is expressed in type III taste cells that respond to sour stimuli and genetic elimination of cells expressing PKD2L1 substantially reduces chorda tympani nerve responses to sour taste stimuli. However, the contribution of PKD2L1 and PKD1L3 ...
متن کاملSour taste finds closure in a potassium channel.
Taste cells in taste buds of the mammalian tongue and oral cavity can detect five basic modalities: sweet, bitter, umami, salty, and sour. Each taste cell expresses distinct molecular sensors, such as G protein-coupled receptors or ion channels, which detect tastants (i.e., chemical stimuli that elicit taste sensation) and initiate an intracellular response that culminates in membrane depolariz...
متن کاملSour Ageusia in Two Individuals Implicates Ion Channels of the ASIC and PKD Families in Human Sour Taste Perception at the Anterior Tongue
BACKGROUND The perception of sour taste in humans is incompletely understood at the receptor cell level. We report here on two patients with an acquired sour ageusia. Each patient was unresponsive to sour stimuli, but both showed normal responses to bitter, sweet, and salty stimuli. METHODS AND FINDINGS Lingual fungiform papillae, containing taste cells, were obtained by biopsy from the two p...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0602702103